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Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group.

ABSTRACT: Palladium-catalyzed methylene ?-C(sp3)-H arylation of aliphatic ketones using a transient directing group is developed. The use of ?-benzyl ?-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)-H bond activation.

SUBMITTER: Hong K

PROVIDER: S-EPMC5640319 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group.

Hong Kai K Park Hojoon H Yu Jin-Quan JQ

ACS catalysis 20170913 10

Palladium-catalyzed methylene β-C(sp3)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)-H bond activation. ...[more]

PMID: 29038742

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