Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes.

ABSTRACT:

Background

Cells are able to communicate and coordinate their function within tissues via secreted factors. Aberrant secretion by cancer cells can modulate this intercellular communication, in particular in highly organised tissues such as the liver. Hepatocytes, the major cell type of the liver, secrete Dickkopf (Dkk), which inhibits Wnt/ β-catenin signalling in an autocrine and paracrine manner. Consequently, Dkk modulates the expression of Wnt/ β-catenin target genes. We present a mathematical model that describes the autocrine and paracrine regulation of hepatic gene expression by Dkk under wild-type conditions as well as in the presence of mutant cells.

Results

Our spatial model describes the competition of Dkk and Wnt at receptor level, intra-cellular Wnt/ β-catenin si

SUBMITTER: Hartung N 

PROVIDER: S-EPMC5640931 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature