Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5641084 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Li Yecheng Y Yang Xiaodong X Wu Yong Y Zhao Kui K Ye Zhenyu Z Zhu Junjia J Xu Xiaohui X Zhao Xin X Xing Chungen C
Oncotarget 20170513 42
B7-H3 (B7 homologue 3, CD276) is a member of the B7 immunoregulatory family and promotes tumor progression. The present study demonstrated that B7-H3 promotes gastric cancer cell migration and invasion. shRNA-mediated B7-H3 silencing in the N87 gastric cancer cell line suppressed cell migration and invasion <i>in vitro</i> and <i>in vivo</i>; downregulated metastasis-associated CXCR4; and inhibited AKT, ERK, and Jak2/Stat3 phosphorylation. B7-H3-silenced cells injected into the tail veins of 4-w ...[more]