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Association between MPHOSPH6 gene polymorphisms and IgA nephropathy risk in a Chinese Han population.


ABSTRACT: Multiple genetic and environmental factors together contribute to the risk of IgA nephropathy (IgAN). MPHOSPH6 play an important role in the recruitment of the exosome to the pre-rRNA. However, to date, little information is found about the association between MPHOSPH6 polymorphisms and the IgAN risk. In this case-control study, we genotyped five single nucleotide polymorphisms (SNPs) in MPHOSPH6 gene in 416 IgAN cases and 495 controls using Sequenom Mass-ARRAY technology and evaluated their association with IgAN using the ?2 and genetic model analysis. In the allelic model analysis, we determined rs1056654 was associated with a 0.774-fold decrease in the risk of IgAN (95%CI= 0.630-0.952; p = 0.015). In the genetic model analysis, we found that the "C/C" genotype of rs1056675 was associated with an increased risk of IgAN based on the codominant model (OR =1.48; 95% CI=1.03-2.13; p=0.033) and recessive model (OR =1.52; 95% CI=1.11-2.09; p=0.0095). The "G/A-A/A" genotype of rs1056654 was associated with a decreased risk of IgAN based on the dominant model (OR =0.75; 95% CI=0.58-0.98; p=0.032) and log-additvie model (OR =0.78; 95% CI=0.64-0.96; p=0.0188). Our data suggested that gene polymorphisms in the MPHOSPH6 may exert influences IgAN susceptibility in a Chinese Han population.

SUBMITTER: Yang X 

PROVIDER: S-EPMC5641137 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Association between <i>MPHOSPH6</i> gene polymorphisms and IgA nephropathy risk in a Chinese Han population.

Yang Xiaohong X   Zhang Yin Y   Li Wenning W   Su Yan Y   Niu Dan D   Wang Yanni Y   Huang Haiyang H   Han Hui H   Zhang Daofa D   Xie Maowei M   Su Huiluan H   Xu Wentan W   Wei Jiali J  

Oncotarget 20170801 42


Multiple genetic and environmental factors together contribute to the risk of IgA nephropathy (IgAN). <i>MPHOSPH6</i> play an important role in the recruitment of the exosome to the pre-rRNA. However, to date, little information is found about the association between <i>MPHOSPH6</i> polymorphisms and the IgAN risk. In this case-control study, we genotyped five single nucleotide polymorphisms (SNPs) in <i>MPHOSPH6</i> gene in 416 IgAN cases and 495 controls using Sequenom Mass-ARRAY technology an  ...[more]

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