Ontology highlight
ABSTRACT:
SUBMITTER: Tavares MT
PROVIDER: S-EPMC5641951 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20170905 10
Only a handful of therapies offer significant improvement in the overall survival in cases of melanoma, a cancer whose incidence has continued to rise in the past 30 years. In our effort to identify potent and isoform-selective histone deacetylase (HDAC) inhibitors as a therapeutic approach to melanoma, a series of new HDAC6 inhibitors based on the nexturastat A scaffold were prepared. The new analogues <b>4d</b>, <b>4e</b>, and <b>7b</b> bearing added hydrophilic substituents, so as to establis ...[more]