Ontology highlight
ABSTRACT: Context
Inflammatory infiltrates are sometimes present in solid tumors and may be coupled to clinical behavior or etiology. Infectious viruses contribute to tumorigenesis in a significant fraction of human neoplasias.Objective
Characterize inflammatory infiltrates and possible viral transcription in primary hyperparathyroidism.Design
From the period 2007 to 2016, a total of 55 parathyroid tumors (51 adenomas and 4 hyperplasias) with prominent inflammatory infiltrates were identified from more than 2000 parathyroid tumors in the pathology archives, and investigated by immunohistochemistry for CD4, CD8, CD20 and CD45 and scored as +0, +1 or +2. Clinicopathological data were compared to 142 parathyroid adenomas without histological evidence of inflammation. Transcriptome sequencing was performed for 13 parathyroid tumors (four inflammatory, 9 non-inflammatory) to identify potential viral transcripts.Results
Tumors had prominent germinal center-like nodular (+2) lymphocytic infiltrates consisting of T and B lymphocytes (31%) and/or diffuse (+1-2) infiltrates of predominantly CD8+ T lymphocytes (84%). In the majority of cases with adjacent normal parathyroid tissue, the normal rim was unaffected by the inflammatory infiltrates (96%). Presence of inflammatory infiltrates was associated with higher levels of serum-PTH (P?=?0.007) and oxyphilic differentiation (P?=?0.002). Co-existent autoimmune disease was observed in 27% of patients with inflammatory infiltrates, which in turn was associated with oxyphilic differentiation (P?=?0.041). Additionally, prescription of anti-inflammatory drugs was associated with lower serum ionized calcium (P?=?0.037).Conclusions
No evidence of virus-like sequences in the parathyroid tumors could be found by transcriptome sequencing, suggesting that other factors may contribute to attract the immune system to the parathyroid tumor tissue.
SUBMITTER: Haglund F
PROVIDER: S-EPMC5642267 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Haglund Felix F Hallström Björn M BM Nilsson Inga-Lena IL Höög Anders A Juhlin C Christofer CC Larsson Catharina C
European journal of endocrinology 20170830 6
<h4>Context</h4>Inflammatory infiltrates are sometimes present in solid tumors and may be coupled to clinical behavior or etiology. Infectious viruses contribute to tumorigenesis in a significant fraction of human neoplasias.<h4>Objective</h4>Characterize inflammatory infiltrates and possible viral transcription in primary hyperparathyroidism.<h4>Design</h4>From the period 2007 to 2016, a total of 55 parathyroid tumors (51 adenomas and 4 hyperplasias) with prominent inflammatory infiltrates were ...[more]