Detection of membrane-bound and soluble antigens by magnetic levitation.
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ABSTRACT:
SUBMITTER: Andersen MS
PROVIDER: S-EPMC5642277 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Detection of membrane-bound and soluble antigens by magnetic levitation.
Andersen Mikkel Schou MS Howard Emily E Lu Shulin S Richard Matthew M Gregory Mark M Ogembo Gordon G Mazor Ofer O Gorelik Pavel P Shapiro Nathan I NI Sharda Anish V AV Ghiran Ionita I
Lab on a chip 20171001 20
Magnetic levitation is a technique for measuring the density and the magnetic properties of objects suspended in a paramagnetic field. We describe a novel magnetic levitation-based method that can specifically detect cell membrane-bound and soluble antigens by measurable changes in levitation height that result from the formation of antibody-coated bead and antigen complex. We demonstrate our method's ability to sensitively detect an array of membrane-bound and soluble antigens found in blood, i ...[more]
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