Ontology highlight
ABSTRACT:
SUBMITTER: Ha K
PROVIDER: S-EPMC5642383 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Ha Kyungsik K Kim Hong-Gee HG Lee Hwajin H
NPJ genomic medicine 20170403
Somatic mutation rates in cancer differ across the genome in a cancer cell-type specific manner. Although key factors that contribute to the differences were identified, the major cancer progression stage when these factors associate with the mutation variance remained poorly investigated. Here, we analyzed whole-genome sequencing data of pre-cancerous and matching cancer tissues from 173 individuals and 423 normal tissue chromatin features to determine the critical stage of these features contr ...[more]