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LncSHRG promotes hepatocellular carcinoma progression by activating HES6.


ABSTRACT: Hepatocellular carcinoma, one of the most common cancers, leads to mass mortality worldwide currently. However, the underlying mechanism of its oncogenesis remains to be elucidated. Here we identified that a long noncoding RNA, lncSHRG, was greatly upregulated in human hepatocellular carcinoma samples. We found that lncSHRG was essential for liver cancer cell proliferation and tumor propagation in mice. In mechanism, lncSHRG recruits SATB1 to bind to HES6 promoter and initiates HES6 expression. HES6, which is highly expressed in hepatocellular carcinoma, promotes tumor cell proliferation. High expression level of HES6 is positively correlated with clinical severity and poor prognosis of people with hepatocellular carcinoma. Altogether, our research provides a new insight on the mechanism of hepatocellular carcinoma progression.

SUBMITTER: Xu YC 

PROVIDER: S-EPMC5642582 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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LncSHRG promotes hepatocellular carcinoma progression by activating <i>HES6</i>.

Xu Ying-Chen YC   Liang Chao-Jie CJ   Zhang Dong-Xin DX   Li Guan-Qun GQ   Gao Xia X   Fu Jian-Zhu JZ   Xia Feng F   Ji Jia-Jun JJ   Zhang Li-Jun LJ   Li Guang-Ming GM   Wu Ji-Xiang JX  

Oncotarget 20170803 41


Hepatocellular carcinoma, one of the most common cancers, leads to mass mortality worldwide currently. However, the underlying mechanism of its oncogenesis remains to be elucidated. Here we identified that a long noncoding RNA, <i>lncSHRG</i>, was greatly upregulated in human hepatocellular carcinoma samples. We found that lncSHRG was essential for liver cancer cell proliferation and tumor propagation in mice. In mechanism, <i>lncSHRG</i> recruits SATB1 to bind to <i>HES6</i> promoter and initia  ...[more]

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