Ontology highlight
ABSTRACT:
SUBMITTER: Dasgupta A
PROVIDER: S-EPMC5642719 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Dasgupta Ananya A Baby Nimmi N Krishna Kumar K Hakim Muhammad M Wong Yuk Peng YP Behnisch Thomas T Soong Tuck Wah TW Sajikumar Sreedharan S
Proceedings of the National Academy of Sciences of the United States of America 20170925 41
The hippocampal area <i>Cornu Ammonis</i> (CA) CA2 is important for social interaction and is innervated by Substance P (SP)-expressing supramammillary (SuM) nucleus neurons. SP exerts neuromodulatory effects on pain processing and central synaptic transmission. Here we provide evidence that SP can induce a slowly developing NMDA receptor- and protein synthesis-dependent potentiation of synaptic transmission that can be induced not only at entorhinal cortical (EC)-CA2 synapses but also at long-t ...[more]