Ontology highlight
ABSTRACT:
SUBMITTER: Galtieri DJ
PROVIDER: S-EPMC5643088 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Galtieri Daniel J DJ Estep Chad M CM Wokosin David L DL Traynelis Stephen S Surmeier D James DJ
eLife 20171005
Burst spiking in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-directed behavior. It is widely believed that this spiking mode depends upon an interaction between synaptic activation of N-methyl-D-aspartate receptors (NMDARs) and intrinsic oscillatory mechanisms. However, the role of specific neural networks in burst generation has not been defined. To begin filling this gap, SNc glutamatergic synapses arising from pedunculop ...[more]