Ontology highlight
ABSTRACT:
SUBMITTER: Qin Y
PROVIDER: S-EPMC5643141 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Qin Yuting Y Wu Lingling L Ouyang Ye Y Zhou Ping P Zhou Haibo H Wang Yan Y Ma Jianyang J Zhang Jinsong J Chen Yanan Y Qian Jie J Tang Yuanjia Y Shen Nan N
PLoS genetics 20171004 10
MicroRNAs are universal post-transcriptional regulators in genomes. They have the ability of buffering gene expressional programs, contributing to robustness of biological systems and playing important roles in development, physiology and diseases. Here, we identified a microRNA, miR-125a, as a positive regulator of granulopoiesis. MiR125a knockout mice show reduced infiltration of neutrophils in the lung and alleviated tissue destruction after endotoxin challenge as a consequence of decreased n ...[more]