Ontology highlight
ABSTRACT:
SUBMITTER: Peek SL
PROVIDER: S-EPMC5643215 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Peek Stacey L SL Mah Kar Men KM Weiner Joshua A JA
Cellular and molecular life sciences : CMLS 20170619 22
The protocadherins (Pcdhs), which make up the most diverse group within the cadherin superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including ~60 proteins encoded by the tandem Pcdha, Pcdhb, and Pcdhg gene clusters and another ~10 non-clustered Pcdhs, in the regulation of neural development have continually accumulated, with a significant expansion of the field over the past decade. Here, we review the many roles played by clustered and non-clustered Pcdhs in ...[more]