Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families.

ABSTRACT:

Background & aims

Crohn's disease (CD) is a highly heritable disease that is particularly common in the Ashkenazi Jewish population. We studied 2 large Ashkenazi Jewish families with a high prevalence of CD in an attempt to identify novel genetic risk variants.

Methods

Ashkenazi Jewish patients with CD and a positive family history were recruited from the University College London Hospital. We used genome-wide, single-nucleotide polymorphism data to assess the burden of common CD-associated risk variants and for linkage analysis. Exome sequencing was performed and rare variants that were predicted to be deleterious and were observed at a high frequency in cases were prioritized. We undertook within-family association analysis after imputation and assessed candidate variants

SUBMITTER: Levine AP 

PROVIDER: S-EPMC5643259 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature