Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC5643384 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wang Jianrong J He Nanhai N Zhang Na N Quan Dexian D Zhang Shuo S Zhang Caroline C Yu Ruth T RT Atkins Annette R AR Zhu Ruihong R Yang Chunhui C Cui Ying Y Liddle Christopher C Downes Michael M Xiao Hui H Zheng Ye Y Auwerx Johan J Evans Ronald M RM Leng Qibin Q
Nature communications 20171016 1
Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and maturation of thymocytes whose TCRs display intermediate affinity to self pMHCs for effective immunity, but whether transcriptional regulation helps conserve positively selected thymocytes from being purge ...[more]