Ontology highlight
ABSTRACT:
SUBMITTER: Xia JB
PROVIDER: S-EPMC5643404 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Xia Jing-Bo JB Wu Hai-Yan HY Lai Bing-Lin BL Zheng Li L Zhou Deng-Cheng DC Chang Zao-Shang ZS Mao Cheng-Zhou CZ Liu Guang-Hui GH Park Kyu-Sang KS Zhao Hui H Kim Soo-Ki SK Song Guo-Hua GH Cai Dong-Qing DQ Qi Xu-Feng XF
Scientific reports 20171016 1
Vascular endothelial growth factor (VEGF) plays important roles in improvement of cardiac function following myocardial infarction (MI). However, the lack of a steerable delivery system of VEGF targeting the infarcted myocardium reduces the therapeutic efficacy and safety. Here, we constructed a series of lentiviral vector systems which could express a fusion protein consisted of a collagen-binding domain (CBD) and hVEGF (CBDhVEGF), under the control of 5HRE-hCMVmp (5HRE), the hypoxia-inducible ...[more]