Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers.
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ABSTRACT:
SUBMITTER: De Gasperi R
PROVIDER: S-EPMC5643439 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers.
De Gasperi Rita R Hamidi Sayyed S Harlow Lauren M LM Ksiezak-Reding Hanna H Bauman William A WA Cardozo Christopher P CP
Scientific reports 20171016 1
Exosomes are vesicles released by many eukaryotic cells; their cargo includes proteins, mRNA and microRNA (miR) that can be transferred to recipient cells and regulate cellular processes in an autocrine or paracrine manner. While cells of the myoblast lineage secrete exosomes, it is not known whether skeletal muscle fibers (myofibers) release exosomes. In this study, we found that cultured myofibers release nanovesicles that have bilamellar membranes and an average size of 60-130 nm, contain typ ...[more]
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