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Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer.


ABSTRACT: We aimed to investigate the effect of hotspot variations of XRCC2 gene on the risk of head and neck cancer (HNC) in 400 patients and 400 controls. Five polymorphisms of XRCC2 gene G4234C (rs3218384), G4088T (rs3218373), G3063A (rs2040639), R188H (rs3218536) and rs7802034 were analyzed using Allele- specific polymerase chain reaction (ARMS-PCR) followed by sequence analysis. For rs3218373, the GG genotype indicated a statistically significant 3-fold increased risk of HNC (P?

SUBMITTER: Saeed S 

PROVIDER: S-EPMC5643489 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer.

Saeed Soma S   Mahjabeen Ishrat I   Sarwar Romana R   Bashir Kashif K   Kayani Mahmood Akhtar MA  

Scientific reports 20171016 1


We aimed to investigate the effect of hotspot variations of XRCC2 gene on the risk of head and neck cancer (HNC) in 400 patients and 400 controls. Five polymorphisms of XRCC2 gene G4234C (rs3218384), G4088T (rs3218373), G3063A (rs2040639), R188H (rs3218536) and rs7802034 were analyzed using Allele- specific polymerase chain reaction (ARMS-PCR) followed by sequence analysis. For rs3218373, the GG genotype indicated a statistically significant 3-fold increased risk of HNC (P < 0.001) after multiva  ...[more]

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