Ontology highlight
ABSTRACT:
SUBMITTER: Jeans AF
PROVIDER: S-EPMC5643522 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Jeans Alexander F AF van Heusden Fran C FC Al-Mubarak Bashayer B Padamsey Zahid Z Emptage Nigel J NJ
Cell reports 20171001 2
Voltage-dependent Ca<sup>2+</sup> channels (VGCC) represent the principal source of Ca<sup>2+</sup> ions driving evoked neurotransmitter release at presynaptic boutons. In mammals, presynaptic Ca<sup>2+</sup> influx is mediated mainly via P/Q-type and N-type VGCC, which differ in their properties. Changes in their relative contributions tune neurotransmission both during development and in Hebbian plasticity. However, whether this represents a functional motif also present in other forms of acti ...[more]