Asthma with bronchial hypersecretion: expression of mucins and toll-like receptors in sputum and blood.

ABSTRACT: Asthma with bronchial hypersecretion is a type of asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC).

Objectives

1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion.

Materials and methods

Cross-sectional study which included 43 non-smoking asthmatic patients without bronchiectasis, 19 with bronchiectasis, and 24 without bronchial hypersecretion. All patients underwen

SUBMITTER: Crespo-Lessmann A 

PROVIDER: S-EPMC5644553 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature