Ontology highlight
ABSTRACT:
SUBMITTER: Moustakim M
PROVIDER: S-EPMC5644722 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Moustakim Moses M Clark Peter G K PGK Hay Duncan A DA Dixon Darren J DJ Brennan Paul E PE
MedChemComm 20160907 12
In the last five years, the development of inhibitors of bromodomains has emerged as an area of intensive worldwide research. Emerging evidence has implicated a number of non-BET bromodomains in the onset and progression of diseases such as cancer, HIV infection and inflammation. The development and use of small molecule chemical probes has been fundamental to pre-clinical evaluation of bromodomains as targets. Recent efforts are described highlighting the development of potent, selective and ce ...[more]