Ontology highlight
ABSTRACT:
SUBMITTER: Salim AA
PROVIDER: S-EPMC5645021 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Salim Angela A AA Cho Kwang-Jin KJ Tan Lingxiao L Quezada Michelle M Lacey Ernest E Hancock John F JF Capon Robert J RJ
Organic letters 20140919 19
During a search for inhibitors of oncogenic K-Ras, we detected two known and two new examples of the rare neoantimycin structure class from a liquid cultivation of Streptomyces orinoci, and reassigned/assigned structures to all based on detailed spectroscopic analysis and microscale C3 Marfey's and C3 Mosher chemical degradation/derivatization/analysis. SAR investigations inclusive of the biosynthetically related antimycins and respirantin, and synthetic benzoxazolone, documented a unique N-form ...[more]