Ontology highlight
ABSTRACT:
SUBMITTER: Cornelia Koeberle S
PROVIDER: S-EPMC5645322 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cornelia Koeberle Solveigh S Tanaka Shinji S Kuriu Toshihiko T Iwasaki Hirohide H Koeberle Andreas A Koeberle Andreas A Schulz Alexander A Helbing Dario-Lucas DL Yamagata Yoko Y Morrison Helen H Okabe Shigeo S
Scientific reports 20171017 1
The roles of calcium-calmodulin-dependent protein kinase II-alpha (CaMKIIα) in the expression of long-term synaptic plasticity in the adult brain have been extensively studied. However, how increased CaMKIIα activity controls the maturation of neuronal circuits remains incompletely understood. Herein, we show that pyramidal neurons without CaMKIIα activity upregulate the rate of spine addition, resulting in elevated spine density. Genetic elimination of CaMKIIα activity specifically eliminated t ...[more]