Switching to PegIFN?-2b leads to HBsAg loss in patients with low HBsAg levels and HBV DNA suppressed by NAs.
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ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC5645387 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Switching to PegIFNα-2b leads to HBsAg loss in patients with low HBsAg levels and HBV DNA suppressed by NAs.
Huang Jing J Zhang Ka K Chen Wenli W Liao Jinyao J Luo Xiaodan X Chen Ren R
Scientific reports 20171017 1
Patients with low hepatitis B surface antigen (HBsAg) levels and hepatitis B virus (HBV) DNA suppression by nucleos(t)ide analogues (NAs) achieve high rate of HBsAg loss through switching to PegIFNα in pre-registration study. The aim of this study was to achieve higher rate of HBsAg loss through extended PegIFN treatment. 98 patients with HBsAg < 2,000 IU/ml and HBV DNA < 20 IU/ml were randomized to receive PegIFNα-2b or continuing NA therapy for 60 weeks. At the end of treatment (EOT) and end o ...[more]
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