Ontology highlight
ABSTRACT:
SUBMITTER: Hewing B
PROVIDER: S-EPMC5645401 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Hewing Bernd B Ludwig Antje A Dan Cristian C Pötzsch Max M Hannemann Carmen C Petry Andreas A Lauer Dilyara D Görlach Agnes A Kaschina Elena E Müller Dominik N DN Baumann Gert G Stangl Verena V Stangl Karl K Wilck Nicola N
Scientific reports 20171017 1
Management of protein homeostasis by the ubiquitin-proteasome system is critical for atherosclerosis development. Recent studies showed controversial results on the role of immunoproteasome (IP) subunit β5i/LMP7 in maintenance of protein homeostasis under cytokine induced oxidative stress. The present study aimed to investigate the effect of β5i/LMP7-deficiency on the initiation and progression of atherosclerosis as a chronic inflammatory, immune cell driven disease. LDLR<sup>-/-</sup>LMP7<sup>- ...[more]