Ontology highlight
ABSTRACT:
SUBMITTER: Wu HC
PROVIDER: S-EPMC5645609 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Wu Hsin-Chieh HC Wu Hsin-Chieh HC Lin Yu-Ching YC Liu Cheng-Hsin CH Chung Hsiang-Ching HC Wang Ya-Ting YT Lin Ya-Wen YW Ma Hsin-I HI Tu Pang-Hsien PH Lawler Sean E SE Chen Ruey-Hwa RH
Nature communications 20140101
The promyelocytic leukaemia (PML) protein controls multiple tumour suppressive functions and is downregulated in diverse types of human cancers through incompletely characterized post-translational mechanisms. Here we identify USP11 as a PML regulator by RNAi screening. USP11 deubiquitinates and stabilizes PML, thereby counteracting the functions of PML ubiquitin ligases RNF4 and the KLHL20-Cul3 (Cullin 3)-Roc1 complex. We find that USP11 is transcriptionally repressed through a Notch/Hey1-depen ...[more]