Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis.
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ABSTRACT:
SUBMITTER: Vellinga NAR
PROVIDER: S-EPMC5646128 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis.
Vellinga Namkje A R NAR Boerma E Christiaan EC Koopmans Matty M Donati Abele A Dubin Arnaldo A Shapiro Nathan I NI Pearse Rupert M RM van der Voort Peter H J PHJ Dondorp Arjen M AM Bafi Tony T Fries Michael M Akarsu-Ayazoglu Tulin T Pranskunas Andrius A Hollenberg Steven S Balestra Gianmarco G van Iterson Mat M Sadaka Farid F Minto Gary G Aypar Ulku U Hurtado F Javier FJ Martinelli Giampaolo G Payen Didier D van Haren Frank F Holley Anthony A Gomez Hernando H Mehta Ravindra L RL Rodriguez Alejandro H AH Ruiz Carolina C Canales Héctor S HS Duranteau Jacques J Spronk Peter E PE Jhanji Shaman S Hubble Sheena S Chierego Marialuisa M Jung Christian C Martin Daniel D Sorbara Carlo C Bakker Jan J Ince Can C
Critical care (London, England) 20171018 1
<h4>Background</h4>Mildly elevated lactate levels (i.e., 1-2 mmol/L) are increasingly recognized as a prognostic finding in critically ill patients. One of several possible underlying mechanisms, microcirculatory dysfunction, can be assessed at the bedside using sublingual direct in vivo microscopy. We aimed to evaluate the association between relative hyperlactatemia, microcirculatory flow, and outcome.<h4>Methods</h4>This study was a predefined subanalysis of a multicenter international point ...[more]
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