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Emerging pharmacologic therapies for primary sclerosing cholangitis.

ABSTRACT: The only currently approved treatment for primary sclerosing cholangitis (PSC) is liver transplantation, with a median time to transplant of 12-18 years after diagnosis. There are a number of emerging drugs that have the potential to meet this critically unmet need that will be summarized and discussed herein.Although the cause of PSC is unknown, there are a number of novel therapeutics under development. These drugs target presumed pathogenic mechanisms largely extrapolated from ex-vivo and in-vivo preclinical models, as well as translational observations.Future therapeutic strategies for PSC may include a multitude of complex pathogenic mechanisms encompassing pathways of immunomodulation, the microbiome and inflammation-related fibrosis.

SUBMITTER: Cheung AC

PROVIDER: S-EPMC5646688 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Emerging pharmacologic therapies for primary sclerosing cholangitis.

Cheung Angela C AC Lazaridis Konstantinos N KN LaRusso Nicholas F NF Gores Gregory J GJ

Current opinion in gastroenterology 20170501 3

<h4>Purpose of review</h4>The only currently approved treatment for primary sclerosing cholangitis (PSC) is liver transplantation, with a median time to transplant of 12-18 years after diagnosis. There are a number of emerging drugs that have the potential to meet this critically unmet need that will be summarized and discussed herein.<h4>Recent findings</h4>Although the cause of PSC is unknown, there are a number of novel therapeutics under development. These drugs target presumed pathogenic me ...[more]

PMID: 28257308

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