Ontology highlight
ABSTRACT:
SUBMITTER: Kumar BV
PROVIDER: S-EPMC5646692 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Kumar Brahma V BV Ma Wenji W Miron Michelle M Granot Tomer T Guyer Rebecca S RS Carpenter Dustin J DJ Senda Takashi T Sun Xiaoyun X Ho Siu-Hong SH Lerner Harvey H Friedman Amy L AL Shen Yufeng Y Farber Donna L DL
Cell reports 20170901 12
Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to infection and vaccination, while in humans, the existence and properties of TRMs remain unclear. Here, we use a unique human tissue resource to determine whether human tissue memory T cells constitute a distinct subset in diverse mucosal and lymphoid tissues. We identify a core transcriptional profile within the CD69<sup>+</sup> subset of memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells in lung and spleen that ...[more]