Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study.
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ABSTRACT:
SUBMITTER: Barrow TM
PROVIDER: S-EPMC5647242 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study.
Barrow Timothy M TM Klett Hagen H Toth Reka R Böhm Jürgen J Gigic Biljana B Habermann Nina N Scherer Dominique D Schrotz-King Petra P Skender Stephanie S Abbenhardt-Martin Clare C Zielske Lin L Schneider Martin M Ulrich Alexis A Schirmacher Peter P Herpel Esther E Brenner Hermann H Busch Hauke H Boerries Melanie M Ulrich Cornelia M CM Michels Karin B KB
The Journal of pathology 20170929 3
Smoking tobacco is a known risk factor for the development of colorectal cancer and for mortality associated with the disease. Smoking has been reported to be associated with changes in DNA methylation in blood and in lung tumour tissues, although there has been scant investigation of how epigenetic factors may be implicated in the increased risk of developing colorectal cancer. To identify epigenetic changes associated with smoking behaviours, we performed epigenome-wide analysis of DNA methyla ...[more]
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