Ontology highlight
ABSTRACT:
SUBMITTER: Bohn JA
PROVIDER: S-EPMC5647330 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bohn Jennifer A JA Thummar Keyur K York Ashley A Raymond Alice A Brown W Clay WC Bieniasz Paul D PD Hatziioannou Theodora T Smith Janet L JL
Nature communications 20171018 1
The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retroviruses via deamination of newly reverse-transcribed viral DNA. Their ability to bind RNA is essential for virion infiltration and antiviral activity, yet the mechanisms of viral RNA recognition are unknown. By screening naturally occurring, polymorphic, non-human primate APOBEC3H variants for biological and crystallization properties, we obtained a 2.24-Å crystal structure of pig-tailed macaque APOBEC3H with bound RNA. ...[more]