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Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

ABSTRACT: Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles indexed in four databases using Medical Subject Heading or Title and Abstract words including COAD, COPD, eosinophil, eosinophilia, eosinopenia from inception to December 2016. Observational studies and randomized controlled trials with parallel groups comparing COPD patients with and without eosinophilia were included. Comparing to the non-eosinophilic group, those with eosinophilic COPD had a similar risk for exacerbation in 12 months [Odds ratio?=?1.07, 95% confidence interval (CI) 0.86-1.32, P?=?0.55] and in-hospital mortality [OR?=?0.52, 95% CI 0.25-1.07]. Eosinophilia was associated with reduced length of hospital stay (P?=?0.04). Subsequent to therapeutic interventions, eosinophilic outpatients performed better in pulmonary function tests [Mean Difference?=?1.64, 95% CI 0.05-3.23, P?

SUBMITTER: Ho J

PROVIDER: S-EPMC5647332 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

Ho Jeffery J Ho Jeffery J He Wajia W Chan Matthew T V MTV Tse Gary G Liu Tong T Wong Sunny H SH Leung Czarina C H CCH Wong Wai T WT Tsang Sharon S Zhang Lin L Chan Rose Y P RYP Gin Tony T Leung Joseph J Lau Benson W M BWM Wu William K K WKK Ngai Shirley P C SPC

Scientific reports 20171018 1

Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles indexed in four databases using Medical Subject Heading or Title and Abstract words including COAD, COPD, eosinophil, eosinophilia, eosinopenia from inception to December 2016. Obse ...[more]

PMID: 29044160

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Project description:BackgroundBlood eosinophils have been suggested as a potential biomarker in chronic obstructive pulmonary disease (COPD), and their stability over time has been investigated in a few studies. However, the association between the stability of blood eosinophils and long-term clinical outcomes in COPD patients has yet to be fully elucidated. This study aimed to evaluate the stability of blood eosinophils and its association with clinical outcomes in COPD patients.MethodsIn total, 299 COPD patients from the Korean Obstructive Lung Disease cohort with at least two blood eosinophil measurements were included. Patients were stratified according to a cut-off of 300 cells/μL, and the association between eosinophil changes and all-cause mortality was analysed. The annual decline in forced expiratory volume in 1 s (FEV1), serial changes in St George's Respiratory Questionnaire score (SGRQ), and exacerbations during follow-up were compared among eosinophil groups.ResultsPatients were stratified into three groups according to the blood eosinophil cut-off: persistently < 300 cells/μL (PL; n = 175), variable (V; n = 68), and persistently ≥300 cells/μL (PH; n = 56). There were no significant differences in baseline characteristics (age, sex, smoking, body mass index, use of inhaled corticosteroids, exacerbations in the previous year, FEV1 (L or % predicted), or emphysema score) among the groups. During a median follow-up of 6.0 years, the PH group had a better survival rate than the PL group (adjusted mortality rate ratio, 0.29; 95% confidence interval, 0.09-0.97; P = 0.045). The PH group also showed improved symptoms and impact domains of SGRQ score compared to the PL group. No difference was found in annual FEV1 decline or exacerbations during follow-up among the groups.ConclusionsPatients with persistently high blood eosinophils had a better survival rate than those with persistently low blood eosinophils. Serial follow-up of blood eosinophils could help to predict outcomes in COPD patients.

Dataset Information

Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

Publications

Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

Similar Datasets

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