Dataset Information

Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.

ABSTRACT: Understanding the genetic structure of Native American populations is important to clarify their diversity, demographic history, and to identify genetic factors relevant for biomedical traits. Here, we show a demographic history reconstruction from 12 Native American whole genomes belonging to six distinct ethnic groups representing the three main described genetic clusters of Mexico (Northern, Southern, and Maya). Effective population size estimates of all Native American groups remained below 2,000 individuals for up to 10,000 years ago. The proportion of missense variants predicted as damaging is higher for undescribed (~?30%) than for previously reported variants (~?15%). Several variants previously associated with biological traits are highly frequent in the Native American genomes. These findings suggest that the demographic and adaptive processes that occurred in these groups shaped their genetic architecture and could have implications in biological processes of the Native Americans and Mestizos of today.

SUBMITTER: Romero-Hidalgo S

PROVIDER: S-EPMC5647344 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.

Romero-Hidalgo Sandra S Ochoa-Leyva Adrián A Garcíarrubio Alejandro A Acuña-Alonzo Victor V Antúnez-Argüelles Erika E Balcazar-Quintero Martha M Barquera-Lozano Rodrigo R Carnevale Alessandra A Cornejo-Granados Fernanda F Fernández-López Juan Carlos JC García-Herrera Rodrigo R García-Herrera Rodrigo R García-Ortíz Humberto H Granados-Silvestre Ángeles Á Granados Julio J Guerrero-Romero Fernando F Hernández-Lemus Enrique E León-Mimila Paola P Macín-Pérez Gastón G Martínez-Hernández Angélica A Menjivar Marta M Morett Enrique E Orozco Lorena L Ortíz-López Guadalupe G Pérez-Villatoro Fernando F Rivera-Morales Javier J Riveros-McKay Fernando F Villalobos-Comparán Marisela M Villamil-Ramírez Hugo H Villarreal-Molina Teresa T Canizales-Quinteros Samuel S Soberón Xavier X

Nature communications 20171018 1

Understanding the genetic structure of Native American populations is important to clarify their diversity, demographic history, and to identify genetic factors relevant for biomedical traits. Here, we show a demographic history reconstruction from 12 Native American whole genomes belonging to six distinct ethnic groups representing the three main described genetic clusters of Mexico (Northern, Southern, and Maya). Effective population size estimates of all Native American groups remained below ...[more]

PMID: 29044207

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Dataset Information

Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.

Publications

Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.

Similar Datasets

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