Ontology highlight
ABSTRACT:
SUBMITTER: Ciregia F
PROVIDER: S-EPMC5647430 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ciregia Federica F Bugliani Marco M Ronci Maurizio M Giusti Laura L Boldrini Claudia C Mazzoni Maria R MR Mossuto Sandra S Grano Francesca F Cnop Miriam M Marselli Lorella L Giannaccini Gino G Urbani Andrea A Lucacchini Antonio A Marchetti Piero P
Scientific reports 20171018 1
Type 2 diabetes is characterized by progressive β cell dysfunction, with lipotoxicity playing a possible pathogenetic role. Palmitate is often used to examine the direct effects of lipotoxicity and it may cause mitochondrial alterations by activating protein acetylation. However, it is unknown whether palmitate influences protein acetylation in β cells. We investigated lysine acetylation in mitochondrial proteins from INS-1E β cells (INS-1E) and in proteins from human pancreatic islets (HPI) aft ...[more]