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Recordings of Caenorhabditis elegans locomotor behaviour following targeted ablation of single motorneurons.


ABSTRACT: Lesioning studies have provided important insight into the functions of brain regions in humans and other animals. In the nematode Caenorhabditis elegans, with a small nervous system of 302 identified neurons, it is possible to generate lesions with single cell resolution and infer the roles of individual neurons in behaviour. Here we present a dataset of ~300 video recordings representing the locomotor behaviour of animals carrying single-cell ablations of 5 different motorneurons. Each file includes a raw video of approximately 27,000 frames; each frame has also been segmented to yield the position, contour, and body curvature of the tracked animal. These recordings can be further analysed using publicly-available software to extract features relevant to behavioural phenotypes. This dataset therefore represents a useful resource for probing the neural basis of behaviour in C. elegans, a resource we hope to augment in the future with ablation recordings for additional neurons.

SUBMITTER: Chew YL 

PROVIDER: S-EPMC5647482 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Recordings of Caenorhabditis elegans locomotor behaviour following targeted ablation of single motorneurons.

Chew Yee Lian YL   Walker Denise S DS   Towlson Emma K EK   Vértes Petra E PE   Yan Gang G   Barabási Albert-László AL   Schafer William R WR  

Scientific data 20171019


Lesioning studies have provided important insight into the functions of brain regions in humans and other animals. In the nematode Caenorhabditis elegans, with a small nervous system of 302 identified neurons, it is possible to generate lesions with single cell resolution and infer the roles of individual neurons in behaviour. Here we present a dataset of ~300 video recordings representing the locomotor behaviour of animals carrying single-cell ablations of 5 different motorneurons. Each file in  ...[more]

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