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Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains.

ABSTRACT: Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyridazine derivative, Pd-catalyzed coupling reactions as well as nucleophilic substitutions have been performed successfully in order to increase the molecular diversity.

SUBMITTER: Hariss L

PROVIDER: S-EPMC5647726 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains.

Hariss Layal L Hadir Kamal Bou KB El-Masri Mirvat M Roisnel Thierry T Grée René R Hachem Ali A

Beilstein journal of organic chemistry 20171010

Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyridazine derivative, Pd-catalyzed coupling reactions as well as nucleophilic ...[more]

PMID: 29062431

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