Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC5648759 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20171019 1
TFPI-2 has recently been recognized as a tumor suppressor, which not only plays a fundamental role in modulation of ECM integrity, but also involves the regulation of many oncogenes. In this study, we investigated the potential mechanism of TFPI-2 in the suppression of breast cancer growth and invasion. We showed that, with either over-expression of TFPI-2 or after treatment with exogenous rTFPI-2, breast cancer cells exhibited reduced proliferation and invasion. We demonstrated that in addition ...[more]