Ontology highlight
ABSTRACT:
SUBMITTER: Kellner C
PROVIDER: S-EPMC5649276 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Kellner Christian C Otte Anna A Cappuzzello Elisa E Klausz Katja K Peipp Matthias M
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 20170908 5
In the last two decades, monoclonal antibodies have revolutionized the therapy of cancer patients. Although antibody therapy has continuously been improved, still a significant number of patients do not benefit from antibody therapy. Therefore, rational optimization of the antibody molecule by Fc engineering represents a major area of translational research to further improve this potent therapeutic option. Monoclonal antibodies are able to trigger a variety of effector mechanisms. Especially Fc ...[more]