Compensatory mutations improve general permissiveness to antibiotic resistance plasmids.
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ABSTRACT:
SUBMITTER: Loftie-Eaton W
PROVIDER: S-EPMC5649373 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Compensatory mutations improve general permissiveness to antibiotic resistance plasmids.
Loftie-Eaton Wesley W Bashford Kelsie K Quinn Hannah H Dong Kieran K Millstein Jack J Hunter Samuel S Thomason Maureen K MK Merrikh Houra H Ponciano Jose M JM Top Eva M EM
Nature ecology & evolution 20170807 9
Horizontal gene transfer mediated by broad-host-range plasmids is an important mechanism of antibiotic resistance spread. While not all bacteria maintain plasmids equally well, plasmid persistence can improve over time, yet no general evolutionary mechanisms have emerged. Our goal was to identify these mechanisms and to assess if adaptation to one plasmid affects the permissiveness to others. We experimentally evolved Pseudomonas sp. H2 containing multidrug resistance plasmid RP4, determined pla ...[more]
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