Ontology highlight
ABSTRACT:
SUBMITTER: Zhou G
PROVIDER: S-EPMC5649510 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zhou Guohong G Duan Yajiang Y Ma Gaoen G Wu Wenyi W Hu Zhengping Z Chen Na N Chee Yewlin Y Cui Jing J Samad Arif A Matsubara Joanne A JA Mukai Shizuo S D'Amore Patricia A PA Lei Hetian H
Investigative ophthalmology & visual science 20171001 12
<h4>Purpose</h4>The murine double minute (MDM)2 is a critical negative regulator of the p53 tumor suppressor, and MDM2 SNP309G is associated with a higher risk of proliferative vitreoretinopathy (PVR); in addition, the MDM2 T309G created using clustered regularly interspaced short palindromic repeats (CRISPR)/associated endonuclease (Cas)9 enhances normal rabbit vitreous-induced expression of MDM2 and survival of primary human retinal pigment epithelial (hRPE) cells in vitro. The goal of this st ...[more]