Unknown

Dataset Information

0

Neuroendocrine Differentiation of Prostate Cancer Metastases Evidenced "in Vivo" by 68Ga-DOTANOC PET/CT: Two Cases.


ABSTRACT: Prostate cancer is the second most commonly diagnosed neoplasm in men. This neoplasm has usually excellent prognosis, mostly consequent to the early diagnosis and the effective hormonal therapy. However, significant percentages of patients treated with total androgen blockade therapy, escape to treatment and evolve toward a more aggressive type of cancer. This clinical entity, named castration-resistant prostate cancer, has few and less effective therapeutic opportunities. Therefore, any additional information concerning possible biological targets to therapy is welcome. Here we describe two cases in which 68Ga-DOTANOC PET/CT evidenced the somatostatin receptor overexpression by prostate metastases. The presence of these receptors may support with a more strong evidence the possibility to administer somatostatin analogs as an adjuvant therapy.

SUBMITTER: Savelli G 

PROVIDER: S-EPMC5649877 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Neuroendocrine Differentiation of Prostate Cancer Metastases Evidenced "in Vivo" by <sup>68</sup>Ga-DOTANOC PET/CT: Two Cases.

Savelli Giordano G   Muni Alfredo A   Barbieri Roberto R   Valmadre Giuseppe G   Biasiotto Giorgio G   Minari Chiara C   Ghimenton Claudio C   Pagani Renato R   Pecini Elisa E   Falcone Matteo M  

World journal of oncology 20140401 2


Prostate cancer is the second most commonly diagnosed neoplasm in men. This neoplasm has usually excellent prognosis, mostly consequent to the early diagnosis and the effective hormonal therapy. However, significant percentages of patients treated with total androgen blockade therapy, escape to treatment and evolve toward a more aggressive type of cancer. This clinical entity, named castration-resistant prostate cancer, has few and less effective therapeutic opportunities. Therefore, any additio  ...[more]

Similar Datasets

| S-EPMC8750461 | biostudies-literature
| S-EPMC4912521 | biostudies-literature
| S-EPMC7450718 | biostudies-literature
| 2202581 | ecrin-mdr-crc
| S-EPMC5493006 | biostudies-literature
| S-EPMC7262225 | biostudies-literature
| S-EPMC8190415 | biostudies-literature
| S-EPMC8484099 | biostudies-literature
| S-EPMC7914329 | biostudies-literature
| S-EPMC7991833 | biostudies-literature