Metabolism shapes the tumor microenvironment.
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ABSTRACT:
SUBMITTER: Reina-Campos M
PROVIDER: S-EPMC5650101 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Metabolism shapes the tumor microenvironment.
Reina-Campos Miguel M Moscat Jorge J Diaz-Meco Maria M
Current opinion in cell biology 20170609
Tumors are strongly influenced by the surrounding normal tissue, which forms a specialized niche termed the tumor microenvironment (TME). The TME is modeled by cancer cells for their own benefit through a complex array of interactions. The identification of new forms of communication within the TME, which are dependent on the tumor's metabolic activity, has expanded our understanding of this heterocellular regulation and has revealed potential therapeutic targets. This review will summarize rece ...[more]
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