Ontology highlight
ABSTRACT:
SUBMITTER: Rajan A
PROVIDER: S-EPMC5650192 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Rajan Akhila A Housden Benjamin E BE Wirtz-Peitz Frederik F Holderbaum Laura L Perrimon Norbert N
Developmental cell 20171001 1
Adipocytes sense systemic nutrient status and systemically communicate this information by releasing adipokines. The mechanisms that couple nutritional state to adipokine release are unknown. Here, we investigated how Unpaired 2 (Upd2), a structural and functional ortholog of the primary human adipokine leptin, is released from Drosophila fat cells. We find that Golgi reassembly stacking protein (GRASP), an unconventional secretion pathway component, is required for Upd2 secretion. In nutrient-r ...[more]