H. pylori attenuates TNBS-induced colitis via increasing mucosal Th2 cells in mice.
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ABSTRACT:
SUBMITTER: Wu YZ
PROVIDER: S-EPMC5650302 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
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<i>H. pylori</i> attenuates TNBS-induced colitis via increasing mucosal Th2 cells in mice.
Wu Yi-Zhong YZ Tan Gao G Wu Fang F Zhi Fa-Chao FC
Oncotarget 20170518 43
There is an epidemiological inverse relationship between <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and Crohn's disease (CD). However, whether <i>H. pylori</i> plays a protective role against CD remains unclear. Since 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis is thought to resemble CD, we investigated whether <i>H. pylori</i> can attenuate TNBS-induced colitis in mice. Here we show that <i>H. pylori</i> can attenuate the severity of TNBS-induced colitis. In additi ...[more]
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