The landscape of transcription errors in eukaryotic cells.
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ABSTRACT:
SUBMITTER: Gout JF
PROVIDER: S-EPMC5650487 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
The landscape of transcription errors in eukaryotic cells.
Gout Jean-Francois JF Li Weiyi W Fritsch Clark C Li Annie A Haroon Suraiya S Singh Larry L Hua Ding D Fazelinia Hossein H Smith Zach Z Seeholzer Steven S Thomas Kelley K Lynch Michael M Vermulst Marc M
Science advances 20171020 10
Accurate transcription is required for the faithful expression of genetic information. To understand the molecular mechanisms that control the fidelity of transcription, we used novel sequencing technology to provide the first comprehensive analysis of the fidelity of transcription in eukaryotic cells. Our results demonstrate that transcription errors can occur in any gene, at any location, and affect every aspect of protein structure and function. In addition, we show that multiple proteins saf ...[more]
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