Ontology highlight
ABSTRACT:
SUBMITTER: Niehues H
PROVIDER: S-EPMC5651197 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Niehues Hanna H Tsoi Lam C LC van der Krieken Danique A DA Jansen Patrick A M PAM Oortveld Merel A W MAW Rodijk-Olthuis Diana D van Vlijmen Ivonne M J J IMJJ Hendriks Wiljan J A J WJAJ Helder Richard W RW Bouwstra Joke A JA van den Bogaard Ellen H EH Stuart Philip E PE Nair Rajan P RP Elder James T JT Zeeuwen Patrick L J M PLJM Schalkwijk Joost J
The Journal of investigative dermatology 20170617 11
Terminally differentiating epidermal keratinocytes express a large number of structural and antimicrobial proteins that are involved in the physical barrier function of the stratum corneum and provide innate cutaneous host defense. Late cornified envelope (LCE) genes, located in the epidermal differentiation complex on chromosome 1, encode a family of 18 proteins of unknown function, whose expression is largely restricted to epidermis. Deletion of two members, LCE3B and LCE3C (LCE3B/C-del), is a ...[more]