External adjustment of unmeasured confounders in a case-control study of benzodiazepine use and cancer risk.

ABSTRACT:

Aims

Previous studies have reported diverging results on the association between benzodiazepine use and cancer risk.

Methods

We investigated this association in a matched case-control study including incident cancer cases during 2002-2009 in the Danish Cancer Registry (n = 94 923) and age- and sex-matched (1:8) population controls (n = 759 334). Long-term benzodiazepine use was defined as ≥500 defined daily doses 1-5 years prior to the index date. We implemented propensity score (PS) calibration using external information on confounders available from a survey of the Danish population. Two PSs were used: The error-prone PS using register-based confounders and the calibrated PS based on both register- and survey-based confounders, retrieved from the Health Interview Survey.

SUBMITTER: Thygesen LC 

PROVIDER: S-EPMC5651330 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature