Ontology highlight
ABSTRACT:
SUBMITTER: Delay-Goyet P
PROVIDER: S-EPMC5651361 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Alzheimer's & dementia (New York, N. Y.) 20161103 4
<h4>Introduction</h4>Tau hyperphosphorylation and neurofibrillary tangles are histopathologic hallmarks of tauopathies. Histamine H3-receptor antagonists have been proposed to reduce tau hyperphosphorylation in preclinical models.<h4>Methods</h4>We evaluated the ability of SAR110894, a selective histamine H3-receptor antagonist, to inhibit tau pathology and prevent cognitive deficits in a tau transgenic mouse model (THY-Tau22).<h4>Results</h4>SAR110894 treatment for 6 months (but not 2 weeks) in ...[more]