Ontology highlight
ABSTRACT:
SUBMITTER: Mi W
PROVIDER: S-EPMC5651844 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nature communications 20171020 1
Recognition of modified histones by "reader" proteins constitutes a key mechanism regulating diverse chromatin-associated processes important for normal and neoplastic development. We recently identified the YEATS domain as a novel acetyllysine-binding module; however, the functional importance of YEATS domain-containing proteins in human cancer remains largely unknown. Here, we show that the YEATS2 gene is highly amplified in human non-small cell lung cancer (NSCLC) and is required for cancer c ...[more]