A New Generation of Arachidonic Acid Analogues as Potential Neurological Agent Targeting Cytosolic Phospholipase A2.
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ABSTRACT:
SUBMITTER: Ng CY
PROVIDER: S-EPMC5651845 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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A New Generation of Arachidonic Acid Analogues as Potential Neurological Agent Targeting Cytosolic Phospholipase A<sub>2</sub>.
Ng Cheng Yang CY Kannan Srinivasaraghavan S Chen Yong Jun YJ Tan Francis Chee Kuan FCK Ong Wee Yong WY Go Mei Lin ML Verma Chandra S CS Low Chian-Ming CM Lam Yulin Y
Scientific reports 20171020 1
Cytosolic phospholipase A<sub>2</sub> (cPLA<sub>2</sub>) is an enzyme that releases arachidonic acid (AA) for the synthesis of eicosanoids and lysophospholipids which play critical roles in the initiation and modulation of oxidative stress and neuroinflammation. In the central nervous system, cPLA<sub>2</sub> activation is implicated in the pathogenesis of various neurodegenerative diseases that involves neuroinflammation, thus making it an important pharmacological target. In this paper, a new ...[more]
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